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KMID : 0378019680110010075
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New Medical Journal
1968 Volume.11 No. 1 p.75 ~ p.98
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Effect of Histamine on Circulatory Pseudoeosinophil and Lymphocyte Counts in Rabbits
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Abstract
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The author investigated the effect of histamine on the circulatory pseudoeosinophil and lymphocyte counts in the normal rabbits and the rabbits treated with either bilateral sham-adrenalectomy, unilateral or bilateral adrenalectomy, hypophysectomy, splenectomy, or cervical section. Histamine was injected intramuscularly 0.25 mg. per kg. of body weight, and changes of the peripheral pseudoeosinophil and lymphocyte counts were observed.
The results of the studies were statistically analysed and discussed, and are summarized below.
1. In the normal animals injected with histamine, a marked pseudoeosinophilia and lymphopenia were noted.
2. In the bilateral adrenalectomized animals, a leukocytosis due to the influence of the operation was temporarily noted, and after a definite period, there was a tendency to decreased numbers of pseudoeosinophils and to relatively increased numbers of lymphocytes.
3. Effect of histamine on changes of pseudoeosinophil and lymphocyte counts in the animals, bilaterally sham .and unilaterally adrenalectomized, is identical essentially with the effect that was noted in the normal animals.
4. Injecting histamine 72 hours after bilateral adrenalectomy, revealed no change in pseudoeosinophil count but the relative lymphocytosis was inhibited. Giving histamine 96 hours after bilateral adrenalectomy, produced no. change in pseudoeosinophil and lymphocyte counts.
5. When histamine was injected in the animals treated with hypophysectomy, splenectomy, or cervical section, pseudoeosinophilia and lymphopenia were noted as in the case of the normal animal injected with his tune alone.
6. The adrenals have a role in the mechanism regulating circulatory pseudoeosinophil and lymphocyte counts in the rabbits.
7. Neither hypophysectomy nor splenectomy has any effect on the abnorml picture of peripheral leukocyte counts induced with histamine administration.
8. The abnormal peripheral leukocyte. counts do not seem to be of central origin.
9. It is uncertain whether the abnormal peripheral leukocyte counts induced with histamine injection are the result of direct influence of histamine on the adrenals or of stimulation by this drug to other organs that nay be controlled by the adrenals.
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